Rich Countries Seek Priority Access to COVID-19 Vaccine

In order for an eventual COVID-19 vaccine to save as many lives as possible, it would require rapid distribution, and to those countries struggling with the highest infection rates. The chances that will happen are slim, say several experts who see an increasingly competitive race for first-access to a potential vaccine.

“We have this beautiful picture of everyone getting the vaccine, but there is no road map on how to do it,” the Associated Press was told by Yuan Qiong Hu, a senior legal and policy adviser at Doctors Without Borders in Geneva.

Hu predicts that the existing structure, in which companies establish patents at every step of vaccine development, will hamper the distribution and development of a vaccine that could be made available to all. “We can’t afford to face these multiple layers of private rights to create a ‘people’s vaccine,’” she told the AP.

Three phases

Several possible vaccines are under development across the world thanks to global efforts, with around a dozen in the early stages of testing. Vaccine development requires any potential remedy to go through a three-phase process that tests the efficacy of the drug while ensuring that side effects do not pose unforeseen risks.

In the first phase, small groups of people receive the trial vaccine. If the vaccine proves successful without any significant health risks among the participants, the process moves to the second phase.

In phase two, the clinical study expands to a group of people who are part of the risk group for whom the vaccine is intended, which in COVID-19 cases would be older people and those vulnerable because of pre-existing illnesses.

The third and final phase tests the vaccine on thousands of people to ensure safety and a proven efficacy to avoid false positives and detect possible allergic reactions or side effects.

Private investment

Several wealthy countries have spent millions to support the rapid development of possible vaccine candidates and ensure a potential vaccine could be manufactured on a large scale. In exchange for these investments, these countries are expected to receive vaccines before others.

The British government has declared that the first 30 million doses of a possible vaccine under development at Oxford University will be earmarked for British citizens. The US became entangled in a diplomatic row with France over the potential future distribution of a French vaccine candidate to which the US expected first access because of its investments.

AstraZeneca, a drug manufacturer that intends to produce Oxford University’s vaccine, has signed an agreement with the US that would guarantee 300 million doses for the US, to be delivered as soon as possible.

The same manufacturer struck a deal with four EU countries to also supply them with 300 million doses. Drug manufacturers appear to be actively goading governments into making early commitments to buy yet-unproven drugs, playing countries against each other as they stand to make giant profits.

While pharmaceutical companies have pledged to provide a not-for-profit version of their vaccines, it is becoming clear that the world’s richest will be the first to receive the vaccines, even if other countries need them much more. Another example of the perverse nature of privatized medicine, it will be the richest, not the sickest, who will receive priority in this global crisis.

Cheap Steroid Emerges as Front-runner in COVID-19 Drug Trial

Scientists are hailing dexamethasone, a readily-available steroid, as a breakthrough COVID-19 treatment after it was found to cut deaths by one-third in the sickest patients, according to trial results released by Oxford University researchers on June 16.

The drug, used normally as an arthritis treatment, is one of six potential COVID-19 treatments being tested through the Randomised Evaluation of COVID-19 Therapy Trial, known as the “Recovery Trial.” 

On Tuesday, results from a trial conducted by Oxford University’s Nuffield Department of Population Health, showed that dexamethasone reduces the chance of death by up to one-third in the sickest COVID-19 patients 

“It is the only drug so far shown to reduce mortality and it reduces it significantly,” said Oxford University Professor of Emerging Infectious Diseases and study co-lead Peter Horby.  

“It is a major breakthrough, I think,” added an optimistic Horby. 

The Recovery Trial’s other chief investigator, Professor Martin Landray, said that in addition to its lifesaving properties, the drug’s wide availability and low cost were also “immensely important.” 

Landray said the results were so promising that dexamethasone should be added to the COVID-19 treatment regime straight away. 

“This is a (trial) result that shows that if patients who have COVID-19 and are on ventilators or are on oxygen are given dexamethasone, it will save lives, and it will do so at a remarkably low cost,” Landray said in an online briefing about the latest results.  

“It’s going to be very hard for any drug really to replace this, given that for less than 50 pounds ($63.26), you can treat eight patients and save a life,” Landray added. 

The British government has already moved to stockpile 200,000 doses of dexamethasone and will immediately begin using it to treat patients in UK hospitals. Governments around the world will undoubtedly follow suit, and researchers say they are working to publish the trial results quickly given the public health importance of its findings.  

The Recovery Trial has been running since March, and is one of many racing to find effective treatments for COVID-19. In addition to low-dose dexamethasone, the trial assessed the impact of HIV treatment lopinavir-ritonavir, antimalarial hydroxychloroquine, antibiotic azithromycin, anti-inflammatory injection tocilizumab, and plasma from recovered COVID-19 patients as potential disease treatments. 

The researchers randomized a total of 2,104 patients to receive dexamethasone 6 mg once per day for ten days, and compared them with 4,321 patients randomized to receive standard treatment alone. Dexamethasone was found to reduce deaths by one-third in ventilated patients, and by one fifth in other patients receiving oxygen only.

Read also: Latest Drug Trials Find Antimalarials Ineffective Against COVID-19